Toxicity Assessment

• Non-carcinogens (cont’d)

• Reference Dose = NOAEL/(UF1 * UF2 * .... * MF)

  • Modifying Factor (MF) (ranges from > 1 to 10 with a default of 1)
    • reflects a qualitative professional assessment of additional uncertainties in the study and in the entire database for the chemical(s) of concern and not explicitly addressed in the uncertainty factors.

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