Toxicity Assessment

• Non-carcinogens (cont’d)

• Reference Dose = NOAEL/(UF1 * UF2 * .... * MF)

  • Uncertainty Factor(s) (UF) (uncertainty factor is set equal to 10)
    • account for variation in general population to protect sensitive subpopulation.
    • extrapolate from animals to humans to account for interspecies variability.
    • estimate a chronic NOAEL derived from a subchronic study.
    • estimate NOAEL from LOAEL.

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