Risk Characterization

Chemical

Computed Dose

(mg/kg-d)

Slope Factor

(mg/kg-d)-1

IELCR

Target

Organ

ABC

4.7E-5

0.029

1.4E-6

Kidney

XYZ

9.5E-6

7.3

6.9E-5

Liver

LMN

8.6E-5

.73

6.2E-5

Kidney

PQR

5.7E-4

.02

1.1E-5

Liver

Total

1.4E-4

Estimation of Carcinogenic Risk

Total IELCR = 1.4E-4 > 10-4 implies possibility of unacceptable exposure

Kidney IELCR = 6.3E-5 < 10-4 implies acceptable exposure

Liver IELCR = 8.9E-5 < 10-4 implies acceptable exposure

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