Federal Risk Assessment Paradigm

Laboratory and field observations of adverse health effects and exposures to particular agents

Information on extrapolation methods for high to low dose and animal to human

Field measurements, estimated exposures, characterization of populations

Hazard identification (Does the agent cause the adverse effect?)

Dose-Response Assessment (What is the relationship

between dose and incidence in humans?)

Exposure Assessment (What exposures are currently experienced

or anticipated under different conditions?)

Risk Characterization (What is the estimated incidence of the

adverse effect in a

given population?)

Development of regulatory options

Evaluation of public health, economic, social, political consequences of regulatory options

Agency decisions and actions

NAS report “ Risk Assessment in the Federal Government” (1983)

Risk Assessment

Research

Risk Management

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